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Lineage of origin in rhabdomyosarcoma informs pharmacological response

Lineage or cell of origin of cancers is often unknown and thus is not a consideration in therapeutic approaches. Alveolar rhabdomyosarcoma (aRMS) is an aggressive childhood cancer for which the cell of origin remains debated. We used conditional genetic mouse models of aRMS to activate the pathognom...

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Auteurs principaux: Abraham, Jinu, Nuñez-Álvarez, Yaiza, Hettmer, Simone, Carrió, Elvira, Chen, Hung-I Harry, Nishijo, Koichi, Huang, Elaine T., Prajapati, Suresh I., Walker, Robert L., Davis, Sean, Rebeles, Jennifer, Wiebush, Hunter, McCleish, Amanda T., Hampton, Sheila T., Bjornson, Christopher R.R., Brack, Andrew S., Wagers, Amy J., Rando, Thomas A., Capecchi, Mario R., Marini, Frank C., Ehler, Benjamin R., Zarzabal, Lee Ann, Goros, Martin W., Michalek, Joel E., Meltzer, Paul S., Langenau, David M., LeGallo, Robin D., Mansoor, Atiya, Chen, Yidong, Suelves, Mònica, Rubin, Brian P., Keller, Charles
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102765/
https://ncbi.nlm.nih.gov/pubmed/25030697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.238733.114
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