Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma

Inhibition of the insulin-like growth factor 1 receptor (Igf1r) is an approach being taken in clinical trials to overcome the dismal outcome for metastatic alveolar rhabdomyosarcoma (ARMS), an aggressive muscle cancer of children and young adults. In our study, we address the potential mechanism(s)...

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Main Authors: Abraham, Jinu, Prajapati, Suresh I., Nishijo, Koichi, Schaffer, Beverly S., Taniguchi, Eri, Kilcoyne, Aoife, McCleish, Amanda T., Nelon, Laura D., Giles, Francis G., Efstratiadis, Argiris, LeGallo, Robin D., Nowak, Brent M., Rubin, Brian P., Malempati, Suman, Keller, Charles
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109806/
https://ncbi.nlm.nih.gov/pubmed/21447712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0695
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