Evidence for an Unanticipated Relationship Between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma

Embryonal rhabdomyosarcoma (eRMS) shows the most myodifferentiation amongst sarcomas, yet the precise cell of origin remains undefined. Using Ptch1, p53 and/or Rb1 conditional mouse models and controlling prenatal or postnatal myogenic cell of origin, we demonstrate that eRMS and undifferentiated pl...

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Detalhes bibliográficos
Main Authors: Rubin, Brian P., Nishijo, Koichi, Chen, Hung-I Harry, Yi, Xiaolan, Schuetze, David P., Pal, Ranadip, Prajapati, Suresh I., Abraham, Jinu, Arenkiel, Benjamin R., Chen, Qing-Rong, Davis, Sean, McCleish, Amanda T., Capecchi, Mario R., Michalek, Joel E., Zarzabal, Lee Ann, Khan, Javed, Yu, Zhongxin, Parham, David M., Barr, Frederic G., Meltzer, Paul S., Chen, Yidong, Keller, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040414/
https://ncbi.nlm.nih.gov/pubmed/21316601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.12.023
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