Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma

BACKGROUND: Alveolar rhabdomyosarcoma (aRMS) is a myogenic childhood sarcoma frequently associated with a translocation-mediated fusion gene, Pax3:Foxo1a. METHODS: We investigated the complementary role of Rb1 loss in aRMS tumor initiation and progression using conditional mouse models. RESULTS: Rb1...

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Bibliografiske detaljer
Main Authors: Kikuchi, Ken, Taniguchi, Eri, Chen, Hung-I Harry, Svalina, Matthew N, Abraham, Jinu, Huang, Elaine T, Nishijo, Koichi, Davis, Sean, Louden, Christopher, Zarzabal, Lee Ann, Recht, Olivia, Bajwa, Ayeza, Berlow, Noah, Suelves, Mònica, Perkins, Sherrie L, Meltzer, Paul S, Mansoor, Atiya, Michalek, Joel E, Chen, Yidong, Rubin, Brian P, Keller, Charles
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177545/
https://ncbi.nlm.nih.gov/pubmed/24274149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2044-5040-3-27
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