The high-affinity D2/D3 agonist D512 protects PC12 cells from 6-OHDA-induced apoptotic cell death and rescues dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

In this study, in vitro and in vivo experiments were carried out with the high-affinity multifunctional D2/D3 agonist D-512 in order to explore its potential neuroprotective effects in models of Parkinson’s disease (PD) and the potential mechanism(s) underlying such properties. Pretreatment with D-5...

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Detalhes bibliográficos
Main Authors: Shah, Mrudang, Rajagopalan, Subramanian, Xu, Liping, Voshavar, Chandrashekhar, Shurubor, Yevgeniya, Beal, Flint, Andersen, Julie K, Dutta, Aloke K
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177263/
https://ncbi.nlm.nih.gov/pubmed/24848702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12767
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