A novel iron (II) preferring dopamine agonist chelator D-607 significantly suppresses α-Syn- and MPTP-induced toxicities in vivo

Here, we report the characterization of a novel hybrid D(2)/D(3) agonist and iron (II) specific chelator, D-607, as a multi-target-directed ligand against Parkinson's disease (PD). In our previously published report, we showed that D-607 is a potent agonist of dopamine (DA) D(2)/D(3) receptors,...

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Udgivet i:Neuropharmacology
Main Authors: Das, Banibrata, Rajagopalan, Subramanian, Joshi, Gnanada S., Xu, Liping, Luo, Dan, Andersen, Julie K., Todi, Sokol V., Dutta, Aloke K.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542047/
https://ncbi.nlm.nih.gov/pubmed/28533164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.05.019
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