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Optimizations of SiRNA Design for the Activation of Gene Transcription by Targeting the TATA-Box Motif

Small interfering RNAs (siRNAs) are widely used to repress gene expression by targeting mRNAs. Some reports reveal that siRNAs can also activate or inhibit gene expression through targeting the gene promoters. Our group has found that microRNAs (miRNAs) could activate gene transcription via interact...

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Bibliografiske detaljer
Main Authors: Fan, Miaomiao, Zhang, Yijun, Huang, Zhuoqiong, Liu, Jun, Guo, Xuemin, Zhang, Hui, Luo, Haihua
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176967/
https://ncbi.nlm.nih.gov/pubmed/25250958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108253
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