Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation

Artificial transcription factors (ATFs) and genomic nucleases based on a DNA binding platform consisting of multiple zinc finger domains are currently being developed for clinical applications. However, no genome-wide investigations into their binding specificity have been performed. We have created...

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Bibliographic Details
Main Authors: Grimmer, Matthew R., Stolzenburg, Sabine, Ford, Ethan, Lister, Ryan, Blancafort, Pilar, Farnham, Peggy J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Synthetic Biology and Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176344/
https://ncbi.nlm.nih.gov/pubmed/25122745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku708
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