Breaking through an epigenetic wall: Re-activation of Oct4 by KRAB-containing designer zinc finger transcription factors

The gene Oct4 encodes a transcription factor critical for the maintenance of pluripotency and self-renewal in embryonic stem cells. In addition, improper re-activation of Oct4 contributes to oncogenic processes. Herein, we describe a novel designer zinc finger protein (ZFP) capable of upregulating t...

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Autores principales: Juárez-Moreno, Karla, Erices, Rafaela, Beltran, Adriana S., Stolzenburg, Sabine, Cuello-Fredes, Mauricio, Owen, Gareth I., Qian, Haili, Blancafort, Pilar
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2013
Materias:
Brief Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592902/
https://ncbi.nlm.nih.gov/pubmed/23314702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.23503
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