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How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells
Ribonucleotides are misincorporated into replicating DNA due to the similarity of deoxyribonucleotides and ribonucleotides, the high concentration of ribonucleotides in the nucleus and the imperfect accuracy of replicative DNA polymerases in choosing the base with the correct sugar. Embedded ribonuc...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4176331/ https://ncbi.nlm.nih.gov/pubmed/25159610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku773 |
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