Removal of Misincorporated Ribonucleotides from Prokaryotic Genomes: An Unexpected Role for Nucleotide Excision Repair

Stringent steric exclusion mechanisms limit the misincorporation of ribonucleotides by high-fidelity DNA polymerases into genomic DNA. In contrast, low-fidelity Escherichia coli DNA polymerase V (pol V) has relatively poor sugar discrimination and frequently misincorporates ribonucleotides. Substitu...

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Detalhes bibliográficos
Main Authors: Vaisman, Alexandra, McDonald, John P., Huston, Donald, Kuban, Wojciech, Liu, Lili, Van Houten, Bennett, Woodgate, Roger
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820734/
https://ncbi.nlm.nih.gov/pubmed/24244177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003878
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