Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal

4-Hydroxy-2-nonenal (HNE) is a reactive α,β-unsaturated aldehyde generated during oxidative stress and subsequent peroxidation of polyunsaturated fatty acids. Here, Werner protein (WRN) was identified as a novel target for modification by HNE. Werner syndrome arises through mutations in the WRN gene...

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Main Authors: Czerwińska, Jolanta, Poznański, Jarosław, Dębski, Janusz, Bukowy, Zuzanna, Bohr, Vilhelm A., Tudek, Barbara, Speina, Elżbieta
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Nucleic Acid Enzymes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176168/
https://ncbi.nlm.nih.gov/pubmed/25170083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku783
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