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Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal
4-Hydroxy-2-nonenal (HNE) is a reactive α,β-unsaturated aldehyde generated during oxidative stress and subsequent peroxidation of polyunsaturated fatty acids. Here, Werner protein (WRN) was identified as a novel target for modification by HNE. Werner syndrome arises through mutations in the WRN gene...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4176168/ https://ncbi.nlm.nih.gov/pubmed/25170083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku783 |
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