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Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA Repair

BACKGROUND: The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by hist...

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Detalhes bibliográficos
Main Authors: Muftuoglu, Meltem, Kusumoto, Rika, Speina, Elzbieta, Beck, Gad, Cheng, Wen-Hsing, Bohr, Vilhelm A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276247/
https://ncbi.nlm.nih.gov/pubmed/18398454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001918
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