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Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast

Replicative aging in yeast is asymmetric–mother cells age but their daughter cells are rejuvenated. Here we identify an asymmetry in pH between mother and daughter cells that underlies aging and rejuvenation. Cytosolic pH increases in aging mother cells, but is more acidic in daughter cells. This is...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Henderson, Kiersten A, Hughes, Adam L, Gottschling, Daniel E
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175738/
https://ncbi.nlm.nih.gov/pubmed/25190112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03504
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