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Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast

Replicative aging in yeast is asymmetric–mother cells age but their daughter cells are rejuvenated. Here we identify an asymmetry in pH between mother and daughter cells that underlies aging and rejuvenation. Cytosolic pH increases in aging mother cells, but is more acidic in daughter cells. This is...

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Библиографические подробности
Главные авторы: Henderson, Kiersten A, Hughes, Adam L, Gottschling, Daniel E
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175738/
https://ncbi.nlm.nih.gov/pubmed/25190112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03504
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