Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells

Steady-state egress of hematopoietic progenitor cells can be rapidly amplified by mobilizing agents such as AMD3100, the mechanism, however, is poorly understood. We report that AMD3100 increased the homeostatic release of the chemokine SDF-1 to the circulation in mice and non-human primates. Neutra...

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Main Authors: Dar, Ayelet, Schajnovitz, Amir, Lapid, Kfir, Kalinkovich, Alexander, Itkin, Tomer, Ludin, Aya, Kao, Wei-Ming, Battista, Michela, Tesio, Melania, Kollet, Orit, Cohen, Neta Netzer, Margalit, Raanan, Buss, Eike C., Baleux, Francoise, Oishi, Shinya, Fujii, Nobutaka, Larochelle, Andre, Dunbar, Cynthia E., Broxmeyer, Hal E., Frenette, Paul S., Lapidot, Tsvee
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175714/
https://ncbi.nlm.nih.gov/pubmed/21494253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.62
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