Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells

Steady-state egress of hematopoietic progenitor cells can be rapidly amplified by mobilizing agents such as AMD3100, the mechanism, however, is poorly understood. We report that AMD3100 increased the homeostatic release of the chemokine SDF-1 to the circulation in mice and non-human primates. Neutra...

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Autori principali: Dar, Ayelet, Schajnovitz, Amir, Lapid, Kfir, Kalinkovich, Alexander, Itkin, Tomer, Ludin, Aya, Kao, Wei-Ming, Battista, Michela, Tesio, Melania, Kollet, Orit, Cohen, Neta Netzer, Margalit, Raanan, Buss, Eike C., Baleux, Francoise, Oishi, Shinya, Fujii, Nobutaka, Larochelle, Andre, Dunbar, Cynthia E., Broxmeyer, Hal E., Frenette, Paul S., Lapidot, Tsvee
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175714/
https://ncbi.nlm.nih.gov/pubmed/21494253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.62
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