Inhibition of the Functional Interplay between Endoplasmic Reticulum (ER) Oxidoreduclin-1α (Ero1α) and Protein-disulfide Isomerase (PDI) by the Endocrine Disruptor Bisphenol A

Bisphenol A (BPA) is an endocrine disruptor that may have adverse effects on human health. We recently isolated protein-disulfide isomerase (PDI) as a BPA-binding protein from rat brain homogenates and found that BPA markedly inhibited PDI activity. To elucidate mechanisms of this inhibition, detail...

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Hauptverfasser: Okumura, Masaki, Kadokura, Hiroshi, Hashimoto, Shoko, Yutani, Katsuhide, Kanemura, Shingo, Hikima, Takaaki, Hidaka, Yuji, Ito, Len, Shiba, Kohei, Masui, Shoji, Imai, Daiki, Imaoka, Susumu, Yamaguchi, Hiroshi, Inaba, Kenji
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175339/
https://ncbi.nlm.nih.gov/pubmed/25122773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.564104
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