Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI

In the endoplasmic reticulum (ER) of eukaryotic cells, Ero1 flavoenzymes promote oxidative protein folding through protein disulphide isomerase (PDI), generating reactive oxygen species (hydrogen peroxide) as byproducts. Therefore, Ero1 activity must be strictly regulated to avoid futile oxidation c...

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Autors principals: Inaba, Kenji, Masui, Shoji, Iida, Hiroka, Vavassori, Stefano, Sitia, Roberto, Suzuki, Mamoru
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957217/
https://ncbi.nlm.nih.gov/pubmed/20834232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.222
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