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Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI
In the endoplasmic reticulum (ER) of eukaryotic cells, Ero1 flavoenzymes promote oxidative protein folding through protein disulphide isomerase (PDI), generating reactive oxygen species (hydrogen peroxide) as byproducts. Therefore, Ero1 activity must be strictly regulated to avoid futile oxidation c...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2957217/ https://ncbi.nlm.nih.gov/pubmed/20834232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.222 |
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