PIM1 Kinase Phosphorylates the Human Transcription Factor FOXP3 at Serine 422 to Negatively Regulate Its Activity under Inflammation

Previous reports have suggested that human CD4(+) CD25(hi)FOXP3(+) T regulatory cells (Tregs) have functional plasticity and may differentiate into effector T cells under inflammation. The molecular mechanisms underlying these findings remain unclear. Here we identified the residue serine 422 of hum...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Li, Zhiyuan, Lin, Fang, Zhuo, Changhua, Deng, Guoping, Chen, Zuojia, Yin, Shuying, Gao, Zhimei, Piccioni, Miranda, Tsun, Andy, Cai, Sanjun, Zheng, Song Guo, Zhang, Yu, Li, Bin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Immunology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175328/
https://ncbi.nlm.nih.gov/pubmed/25096571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586651
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak