Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation

The forkhead family transcription factor FOXP3 is critical for the differentiation and function of CD4(+) CD25(+) regulatory T cells (Treg). How FOXP3 protein level is negatively regulated under the inflammatory microenvironment is largely unknown. Here we report that the combination of transforming...

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Hlavní autoři: Gao, Zhimei, Gao, Yayi, Li, Zhiyuan, Chen, Zuojia, Lu, Daru, Tsun, Andy, Li, Bin
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438759/
https://ncbi.nlm.nih.gov/pubmed/22977658
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