PIM1 Kinase Phosphorylates the Human Transcription Factor FOXP3 at Serine 422 to Negatively Regulate Its Activity under Inflammation

Previous reports have suggested that human CD4(+) CD25(hi)FOXP3(+) T regulatory cells (Tregs) have functional plasticity and may differentiate into effector T cells under inflammation. The molecular mechanisms underlying these findings remain unclear. Here we identified the residue serine 422 of hum...

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Detalhes bibliográficos
Main Authors: Li, Zhiyuan, Lin, Fang, Zhuo, Changhua, Deng, Guoping, Chen, Zuojia, Yin, Shuying, Gao, Zhimei, Piccioni, Miranda, Tsun, Andy, Cai, Sanjun, Zheng, Song Guo, Zhang, Yu, Li, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175328/
https://ncbi.nlm.nih.gov/pubmed/25096571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586651
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