Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation

Regulation of the extent of immune responses is a requirement to maintain self-tolerance and limit inflammatory processes. CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells play a role in regulation. The Foxp3 transcription factor is considered a dominant regulator for Treg cell development and functi...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Deng, Guoping, Nagai, Yasuhiro, Xiao, Yan, Li, Zhiyuan, Dai, Shujia, Ohtani, Takuya, Banham, Alison, Li, Bin, Wu, Shiaw-Lin, Hancock, Wayne, Samanta, Arabinda, Zhang, Hongtao, Greene, Mark I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536430/
https://ncbi.nlm.nih.gov/pubmed/25987564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.638221
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