TGF-β and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3

Expression of FOXP3, a potent gene-specific transcriptional repressor, in regulatory T cells is required to suppress autoreactive and alloreactive effector T cell function. Recent studies have shown that FOXP3 is an acetylated protein in a large nuclear complex and FOXP3 actively represses transcrip...

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Detalhes bibliográficos
Main Authors: Samanta, Arabinda, Li, Bin, Song, Xiaomin, Bembas, Kathryn, Zhang, Geng, Katsumata, Makoto, Saouaf, Sandra J., Wang, Qiang, Hancock, Wayne W., Shen, Yuan, Greene, Mark I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544572/
https://ncbi.nlm.nih.gov/pubmed/18779564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806726105
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