FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

The forkhead family protein FOXP3 acts as a repressor of transcription and is both an essential and sufficient regulator of the development and function of regulatory T cells. The molecular mechanism by which FOXP3-mediated transcriptional repression occurs remains unclear. Here, we report that tran...

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Main Authors: Li, Bin, Samanta, Arabinda, Song, Xiaomin, Iacono, Kathryn T., Bembas, Kathryn, Tao, Ran, Basu, Samik, Riley, James L., Hancock, Wayne W., Shen, Yuan, Saouaf, Sandra J., Greene, Mark I.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838642/
https://ncbi.nlm.nih.gov/pubmed/17360565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700298104
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