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A Residue-specific Shift in Stability and Amyloidogenicity of Antibody Variable Domains
Variable (V) domains of antibodies are essential for antigen recognition by our adaptive immune system. However, some variants of the light chain V domains (V(L)) form pathogenic amyloid fibrils in patients. It is so far unclear which residues play a key role in governing these processes. Here, we s...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4175325/ https://ncbi.nlm.nih.gov/pubmed/25096580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.582247 |
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