Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1

CTB-MPR is a fusion protein between the B subunit of cholera toxin (CTB) and the membrane-proximal region of gp41 (MPR), the transmembrane envelope protein of Human immunodeficiency virus 1 (HIV-1), and has previously been shown to induce the production of anti-HIV-1 antibodies with antiviral functi...

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Autori principali: Lee, Ho-Hsien, Cherni, Irene, Yu, HongQi, Fromme, Raimund, Doran, Jeffrey D., Grotjohann, Ingo, Mittman, Michele, Basu, Shibom, Deb, Arpan, Dörner, Katerina, Aquila, Andrew, Barty, Anton, Boutet, Sébastien, Chapman, Henry N., Doak, R. Bruce, Hunter, Mark S., James, Daniel, Kirian, Richard A., Kupitz, Christopher, Lawrence, Robert M., Liu, Haiguang, Nass, Karol, Schlichting, Ilme, Schmidt, Kevin E., Seibert, M. Marvin, Shoeman, Robert L., Spence, John C. H., Stellato, Francesco, Weierstall, Uwe, Williams, Garth J., Yoon, Chunhong, Wang, Dingjie, Zatsepin, Nadia A., Hogue, Brenda G., Matoba, Nobuyuki, Fromme, Petra, Mor, Tsafrir S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2014
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174873/
https://ncbi.nlm.nih.gov/pubmed/25295172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252514014900
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