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Inhibition of mitochondrial protein import by mutant huntingtin
Mitochondrial dysfunction is associated with neuronal loss in Huntington’s disease (HD), a neurodegenerative disease caused by an abnormal polyglutamine expansion in huntingtin (Htt). However, the mechanisms linking mutant Htt and mitochondrial dysfunction in HD remain unknown. We identify an intera...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4174557/ https://ncbi.nlm.nih.gov/pubmed/24836077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3721 |
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