Inhibition of mitochondrial protein import by mutant huntingtin

Mitochondrial dysfunction is associated with neuronal loss in Huntington’s disease (HD), a neurodegenerative disease caused by an abnormal polyglutamine expansion in huntingtin (Htt). However, the mechanisms linking mutant Htt and mitochondrial dysfunction in HD remain unknown. We identify an intera...

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Autori principali: Yano, Hiroko, Baranov, Sergei V, Baranova, Oxana V, Kim, Jinho, Pan, Yanchun, Yablonska, Svitlana, Carlisle, Diane L, Ferrante, Robert J, Kim, Albert H, Friedlander, Robert M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174557/
https://ncbi.nlm.nih.gov/pubmed/24836077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3721
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