The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity

Melatonin mediates neuroprotection in several experimental models of neurodegeneration. It is not yet known, however, whether melatonin provides neuroprotection in genetic models of Huntington's disease (HD). We report that melatonin delays disease onset and mortality in a transgenic mouse mode...

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Detalhes bibliográficos
Main Authors: Wang, Xin, Sirianni, Ana, Pei, Zhijuan, Cormier, Kerry, Smith, Karen, Jiang, Jiying, Zhou, Shuanhu, Wang, Hui, Zhao, Rong, Yano, Hiroko, Kim, Jeong Eun, Li, Wei, Kristal, Bruce S., Ferrante, Robert J., Friedlander, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213696/
https://ncbi.nlm.nih.gov/pubmed/21994366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3059-11.2011
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