Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

Caspase-mediated cell death contributes to the pathogenesis of motor neuron degeneration in the mutant SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS), along with other factors such as inflammation and oxidative damage. By screening a drug library, we found that melatonin, a...

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Detalhes bibliográficos
Main Authors: Zhang, Yi, Cook, Anna, Kim, Jinho, Baranov, Sergei V., Jiang, Jiying, Smith, Karen, Cormier, Kerry, Bennett, Erik, Browser, Robert P., Day, Arthur L., Carlisle, Diane, Ferrante, Robert J., Wang, Xin, Friedlander, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652329/
https://ncbi.nlm.nih.gov/pubmed/23537713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.03.008
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