Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23

Mutant huntingtin (mHTT), the causative protein in Huntington’s disease (HD), associates with the translocase of mitochondrial inner membrane 23 (TIM23) complex, resulting in inhibition of synaptic mitochondrial protein import first detected in presymptomatic HD mice. The early timing of this event...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Yablonska, Svitlana, Ganesan, Vinitha, Ferrando, Lisa M., Kim, JinHo, Pyzel, Anna, Baranova, Oxana V., Khattar, Nicolas K., Larkin, Timothy M., Baranov, Sergei V., Chen, Ning, Strohlein, Colleen E., Stevens, Donté A., Wang, Xiaomin, Chang, Yue-Fang, Schurdak, Mark E., Carlisle, Diane L., Minden, Jonathan S., Friedlander, Robert M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697818/
https://ncbi.nlm.nih.gov/pubmed/31346086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904101116
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker