Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23

Mutant huntingtin (mHTT), the causative protein in Huntington’s disease (HD), associates with the translocase of mitochondrial inner membrane 23 (TIM23) complex, resulting in inhibition of synaptic mitochondrial protein import first detected in presymptomatic HD mice. The early timing of this event...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Yablonska, Svitlana, Ganesan, Vinitha, Ferrando, Lisa M., Kim, JinHo, Pyzel, Anna, Baranova, Oxana V., Khattar, Nicolas K., Larkin, Timothy M., Baranov, Sergei V., Chen, Ning, Strohlein, Colleen E., Stevens, Donté A., Wang, Xiaomin, Chang, Yue-Fang, Schurdak, Mark E., Carlisle, Diane L., Minden, Jonathan S., Friedlander, Robert M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697818/
https://ncbi.nlm.nih.gov/pubmed/31346086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904101116
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