A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer

Mutations affecting mitochondrial complex I, a multi-subunit assembly that couples electron transfer to proton pumping, are the most frequent cause of heritable mitochondrial diseases. However, the mechanisms by which complex I dysfunction results in disease remain unclear. Here, we describe a Droso...

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Detalhes bibliográficos
Main Authors: Burman, Jonathon L., Itsara, Leslie S., Kayser, Ernst-Bernhard, Suthammarak, Wichit, Wang, Adrienne M., Kaeberlein, Matt, Sedensky, Margaret M., Morgan, Philip G., Pallanck, Leo J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Limited 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174527/
https://ncbi.nlm.nih.gov/pubmed/25085991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.015321
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