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Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain
BACKGROUND: Lack of NDUFS4, a subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase), causes Leigh syndrome (LS), a progressive encephalomyopathy. Knocking out Ndufs4, either systemically or in brain only, elicits LS in mice. In patients as well as in KO mice distinct regions of the bra...
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| Опубликовано в: : | PLoS One |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4732614/ https://ncbi.nlm.nih.gov/pubmed/26824698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148219 |
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