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Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain

BACKGROUND: Lack of NDUFS4, a subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase), causes Leigh syndrome (LS), a progressive encephalomyopathy. Knocking out Ndufs4, either systemically or in brain only, elicits LS in mice. In patients as well as in KO mice distinct regions of the bra...

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Publicado en:PLoS One
Autores principales: Kayser, Ernst-Bernhard, Sedensky, Margaret M., Morgan, Philip G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732614/
https://ncbi.nlm.nih.gov/pubmed/26824698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148219
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