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NER Initiation Factors, DDB2 and XPC, Regulate UV Radiation Response by Recruiting ATR and ATM Kinases to DNA Damage Sites

ATR and ATM kinases are central to the checkpoint activation in response to DNA damage and replication stress. However, the nature of the signal, which initially activates these kinases in response to UV damage, is unclear. Here, we have shown that DDB2 and XPC, two early UV damage recognition facto...

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Detalhes bibliográficos
Main Authors: Ray, Alo, Milum, Keisha, Battu, Aruna, Wani, Gulzar, Wani, Altaf A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174315/
https://ncbi.nlm.nih.gov/pubmed/23422745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.01.003
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