Preserving biological heterogeneity with a permuted surrogate variable analysis for genomics batch correction

Motivation: Sample source, procurement process and other technical variations introduce batch effects into genomics data. Algorithms to remove these artifacts enhance differences between known biological covariates, but also carry potential concern of removing intragroup biological heterogeneity and...

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Detaylı Bibliyografya
Asıl Yazarlar: Parker, Hilary S., Leek, Jeffrey T., Favorov, Alexander V., Considine, Michael, Xia, Xiaoxin, Chavan, Sameer, Chung, Christine H., Fertig, Elana J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
Original Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4173013/
https://ncbi.nlm.nih.gov/pubmed/24907368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu375
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