Transgene Regulation Using the Tetracycline-Inducible TetR-KRAB System after AAV-Mediated Gene Transfer in Rodents and Nonhuman Primates

Numerous studies have demonstrated the efficacy of the Adeno-Associated Virus (AAV)-based gene delivery platform in vivo. The control of transgene expression in many protocols is highly desirable for therapeutic applications and/or safety reasons. To date, the tetracycline and the rapamycin dependen...

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Hauptverfasser: Le Guiner, Caroline, Stieger, Knut, Toromanoff, Alice, Guilbaud, Mickaël, Mendes-Madeira, Alexandra, Devaux, Marie, Guigand, Lydie, Cherel, Yan, Moullier, Philippe, Rolling, Fabienne, Adjali, Oumeya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172479/
https://ncbi.nlm.nih.gov/pubmed/25248159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102538
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