Hepatocyte-Ductal Transdifferentiation Is Mediated by Reciprocal Repression of SOX9 and C/EBPα

Primary hepatocytes rapidly dedifferentiate when cultured in vitro. We have studied the mechanism of hepatocyte dedifferentiation by using two culture media: one that maintains hepatocytes in a differentiated state and another that allows dedifferentiation. We show that dedifferentiation involves pa...

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Bibliografiske detaljer
Main Authors: O'Neill, Kathy E., Thowfeequ, Shifaan, Li, Wan-Chun, Eberhard, Daniel, Dutton, James R., Tosh, David, Slack, Jonathan M.W.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2014
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172464/
https://ncbi.nlm.nih.gov/pubmed/25153359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cell.2014.0032
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