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Single–Base Pair Unwinding and Asynchronous RNA Release by the Hepatitis C Virus NS3 Helicase
Nonhexameric helicases use adenosine triphosphate (ATP) to unzip base pairs in double-stranded nucleic acids (dsNAs). Studies have suggested that these helicases unzip dsNAs in single–base pair increments, consuming one ATP molecule per base pair, but direct evidence for this mechanism is lacking. W...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4172460/ https://ncbi.nlm.nih.gov/pubmed/21940894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1206023 |
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