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The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding

The RNA helicase/protease NS3 plays a central role in the RNA replication of hepatitis C virus (HCV), a cytoplasmic RNA virus that represents a major worldwide health problem. NS3 is, therefore, an important drug target in the effort to combat HCV. Most work has focused on the protease, rather than...

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Detalhes bibliográficos
Main Authors: Pang, Phillip S., Jankowsky, Eckhard, Planet, Paul J., Pyle, Anna Marie
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC125889/
https://ncbi.nlm.nih.gov/pubmed/11867545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.5.1168
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