The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding

The RNA helicase/protease NS3 plays a central role in the RNA replication of hepatitis C virus (HCV), a cytoplasmic RNA virus that represents a major worldwide health problem. NS3 is, therefore, an important drug target in the effort to combat HCV. Most work has focused on the protease, rather than...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Pang, Phillip S., Jankowsky, Eckhard, Planet, Paul J., Pyle, Anna Marie
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2002
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125889/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11867545/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.5.1168
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