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Obesity in Aging Exacerbates Blood–Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer’s Disease

There is growing evidence that obesity has deleterious effects on the brain and cognitive function in the elderly population. However, the specific mechanisms through which aging and obesity interact to promote cognitive decline remain unclear. To test the hypothesis that aging exacerbates obesity-i...

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Détails bibliographiques
Auteurs principaux: Tucsek, Zsuzsanna, Toth, Peter, Sosnowska, Danuta, Gautam, Tripti, Mitschelen, Matthew, Koller, Akos, Szalai, Gabor, Sonntag, William E., Ungvari, Zoltan, Csiszar, Anna
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172034/
https://ncbi.nlm.nih.gov/pubmed/24269929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glt177
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