Role of 20-HETE, TRPC channels, and BK(Ca) in dysregulation of pressure-induced Ca(2+) signaling and myogenic constriction of cerebral arteries in aged hypertensive mice

Hypertension in the elderly substantially increases the risk of stroke and vascular cognitive impairment in part due to an impaired functional adaptation of aged cerebral arteries to high blood pressure. To elucidate the mechanisms underlying impaired autoregulatory protection in aging, hypertension...

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Hlavní autoři: Toth, Peter, Csiszar, Anna, Tucsek, Zsuzsanna, Sosnowska, Danuta, Gautam, Tripti, Koller, Akos, Schwartzman, Michal Laniado, Sonntag, William E., Ungvari, Zoltan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882550/
https://ncbi.nlm.nih.gov/pubmed/24097425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00377.2013
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