Supraphysiological androgen levels induce cellular senescence in human prostate cancer cells through the Src-Akt pathway

BACKGROUND: Prostate cancer (PCa) is the second leading cause of cancer mortality of men in Western countries. The androgen receptor (AR) and AR-agonists (androgens) are required for the development and progression of the normal prostate as well as PCa. However, it is discussed that in addition to t...

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Detalhes bibliográficos
Main Authors: Roediger, Julia, Hessenkemper, Wiebke, Bartsch, Sophie, Manvelyan, Marina, Huettner, Soeren S, Liehr, Thomas, Esmaeili, Mohsen, Foller, Susan, Petersen, Iver, Grimm, Marc-Oliver, Baniahmad, Aria
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171558/
https://ncbi.nlm.nih.gov/pubmed/25216853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-214
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