A Natural Androgen Receptor Antagonist Induces Cellular Senescence in Prostate Cancer Cells

We have previously identified a natural occurring, androgen receptor-specific antagonist. Atraric acid (AA) inhibits the transactivation of the androgen receptor (AR) and androgen-mediated growth of AR-expressing human prostate cancer (PCa) cell lines. Here we show that AA treatment of living cells...

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Publicat a:Mol Endocrinol
Autors principals: Hessenkemper, Wiebke, Roediger, Julia, Bartsch, Sophie, Houtsmuller, Adriaan B., van Royen, Martin E., Petersen, Iver, Grimm, Marc-Oliver, Baniahmad, Aria
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2014
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414792/
https://ncbi.nlm.nih.gov/pubmed/25203674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1170
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