Ligand-dependent Corepressor Acts as a Novel Androgen Receptor Corepressor, Inhibits Prostate Cancer Growth, and Is Functionally Inactivated by the Src Protein Kinase

The activated androgen receptor (AR) promotes prostate cancer (PCa) growth. AR antagonists repress the AR by recruitment of corepressors. Not much is known about the inactivation of AR by corepressors in the presence of agonists (androgens). Here we show that the corepressor LCoR acts as an androgen...

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Autores principales: Asim, Mohammad, Hafeez, Bilal Bin, Siddiqui, Imtiaz Ahmad, Gerlach, Claudia, Patz, Michaela, Mukhtar, Hasan, Baniahmad, Aria
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199458/
https://ncbi.nlm.nih.gov/pubmed/21856747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.292771
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