Ligand-dependent Corepressor Acts as a Novel Androgen Receptor Corepressor, Inhibits Prostate Cancer Growth, and Is Functionally Inactivated by the Src Protein Kinase

The activated androgen receptor (AR) promotes prostate cancer (PCa) growth. AR antagonists repress the AR by recruitment of corepressors. Not much is known about the inactivation of AR by corepressors in the presence of agonists (androgens). Here we show that the corepressor LCoR acts as an androgen...

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Bibliographic Details
Main Authors: Asim, Mohammad, Hafeez, Bilal Bin, Siddiqui, Imtiaz Ahmad, Gerlach, Claudia, Patz, Michaela, Mukhtar, Hasan, Baniahmad, Aria
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199458/
https://ncbi.nlm.nih.gov/pubmed/21856747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.292771
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