CSF sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease

Cellular studies suggest sphingolipids may cause or accelerate amyloid-beta (Aβ) and tau pathology but in vivo human studies are lacking. We determined cerebrospinal fluid (CSF) levels of sphingolipids (ceramides, sphingomyelins), amyloid-beta (Aβ1–42, AβX-38, AβX-40, AβX-42) and tau (T-tau, p-tau18...

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Main Authors: Mielke, Michelle M., Haughey, Norman J., Bandaru, V.V.R., Zetterberg, Henrik, Blennow, Kaj, Andreasson, Ulf, Johnson, Sterling C., Gleason, Carey E., Blazel, Hanna M., Puglielli, Luigi, Sager, Mark A., Asthana, Sanjay, Carlsson, Cynthia M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170854/
https://ncbi.nlm.nih.gov/pubmed/24952994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.05.019
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