Safety and Efficacy of High Dose AAV9 Encoding SERCA2a Delivered by Molecular Cardiac Surgery with Recirculating Delivery (MCARD) in Ovine Ischemic Cardiomyopathy

OBJECTIVE: Therapeutic safety and efficacy are the basic prerequisites for clinical gene therapy. Herein we investigate the effect of high dose MCARD-mediated AAV9/SERCA2a gene delivery on clinical parameters, oxidative stress, humoral and cellular immune response, and cardiac remodeling. METHODS: I...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Katz, Michael G., Fargnoli, Anthony S., Williams, Richard D., Steuerwald, Nury M., Isidro, Alice, Ivanina, Anna V., Sokolova, Inna M., Bridges, Charles R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170593/
https://ncbi.nlm.nih.gov/pubmed/25037619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2014.05.070
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares