AAV6-βARKct gene delivery mediated by molecular cardiac surgery with recirculating delivery (MCARD) in sheep results in robust gene expression and increased adrenergic reserve

OBJECTIVE: Genetic modulation of heart function is a novel therapeutic strategy. We investigated the effect of molecular cardiac surgery with recirculating delivery (MCARD)–mediated carboxyl-terminus of the β-adrenergic receptor kinase (βARKct) gene transfer on cardiac mechanoenergetics and β-adreno...

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Autori principali: Katz, Michael G., Fargnoli, Anthony S., Swain, JaBaris D., Tomasulo, Catherine E., Ciccarelli, Michele, Huang, Z. Maggie, Rabinowitz, Joseph E., Bridges, Charles R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666102/
https://ncbi.nlm.nih.gov/pubmed/22143102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2011.08.048
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