A Pharmacokinetic Analysis of Molecular Cardiac Surgery With Recirculation Mediated Delivery of βARKct Gene Therapy: Developing a Quantitative Definition of the Therapeutic Window

BACKGROUND: Two major problems for translating gene therapy for heart failure therapy are: safe and efficient delivery and the inability to establish a relationship between vector exposure and in vivo effects. We present a pharmacokinetics (PK) analysis of molecular cardiac surgery with recirculatin...

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Päätekijät: FARGNOLI, ANTHONY S., KATZ, MICHAEL G., YARNALL, CHARLES, SUMAROKA, MARINA V., STEDMAN, HANSELL, RABINOWITZ, JOSEPH J., KOCH, WALTER J., BRIDGES, CHARLES R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426308/
https://ncbi.nlm.nih.gov/pubmed/21807332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cardfail.2011.03.011
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