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A Pharmacokinetic Analysis of Molecular Cardiac Surgery With Recirculation Mediated Delivery of βARKct Gene Therapy: Developing a Quantitative Definition of the Therapeutic Window
BACKGROUND: Two major problems for translating gene therapy for heart failure therapy are: safe and efficient delivery and the inability to establish a relationship between vector exposure and in vivo effects. We present a pharmacokinetics (PK) analysis of molecular cardiac surgery with recirculatin...
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主要な著者: | , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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2011
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オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3426308/ https://ncbi.nlm.nih.gov/pubmed/21807332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cardfail.2011.03.011 |
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